|
| |
Phosphatidylserine
(Phosphatidyl Serine; PS)
DESCRIPTION/FUNCTION
- Phosphatidylserine (Phosphatidyl Serine; PS)
is classified as a phospholipid. Its structure is a combination of essential
fatty acid (linoleic or alpha-linolenic), monounsaturated or saturated fatty
acid (stearic, palmitic, oleic, arachidonic), mineral acid (phosphoric),
lipid alcohol (glycerol), and amino acid (serine). Phospholipids are major
components of two-layered cellular membranes (lipid bilayer). They limit the
passage of water and water-soluble compounds through the membrane, anchor
proteins within the membrane, maintain membrane flexibility, facilitate
intracellular signaling, are involved in hormone activity and fat digestion,
plus many other roles. Phospholipids commonly contain one of the following:
choline, ethanolamine, inositol, or serine. PS is the most abundant
phospholipid in the brain.
DRI (RDA or AI for adults)
MAJOR SOURCES
- Soybeans. Animal source not used now because
of mad cow disease (BSE) concerns.
MAINTENANCE/THERAPEUTIC RANGE
POSSIBLE THERAPEUTIC APPLICATIONS
COMMENTS
- Earlier research was done on BC-PS (bovine
cortex PS), but because of concerns of mad cow disease, most manufacturers
have switched to SB-PS (soy bean PS). The fatty acids in BC-PS are mostly
saturated and monounsaturated, whereas the fatty acids in SB-PS are mainly
polyunsaturated. PS can increase levels of neurotransmitters (acetylcholine,
dopamine, serotonin). It can also lower cortisol levels produced by
exercise-induced stress. Start with 200 mg to 300 mg per day for one or two
months. Thereafter, 100 mg per day is usually sufficient.
CAUTIONS
|
